| Title | Alkaloids from Gelsemium elegans |
| Author | Xu, You-Kai |
| Publication | JOURNAL OF NATURAL PRODUCTS |
| Year | 2006 |
| Volume | 69 |
| Issue | 9 |
| Corresponding Author | Yue, JM |
| Abstract | Three new alkaloids, gelsebanine ( 1), 14 alpha-hydroxyelegansamine ( 2), and 14 alpha-hydroxygelsamydine ( 3), and a new extraction artifact, gelsebamine ( 4), together with 12 known alkaloids, were isolated from the stems and leaves of Gelsemium elegans. The structures of 1-4 were determined by spectroscopic methods, especially 2D NMR techniques. Compounds 1-4 were evaluated for cytotoxic activity against four tumor cell lines, and gelsebamine ( 4) selectively inhibited the A-549 human lung adenocarcinoma cell line. |
