| Title | Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus |
| Author | Zhang, Mao-Juan |
| Publication | MOLECULES |
| Year | 2013 |
| Volume | 18 |
| Issue | 8 |
| Corresponding Author | Xu, YK |
| Abstract | Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated. |
