| Title | Flavonoids from Twigs of Millettia pubinervis |
| Author | Na, Zhi |
| Publication | NATURAL PRODUCT COMMUNICATIONS |
| Year | 2014 |
| Volume | 9 |
| Issue | 12 |
| Corresponding Author | Na, Z |
| Abstract | A new flavone, 3-methoxy-5-hydroxy-[2,3:7,8] furanoflavone, pubinerone (1), was isolated from the twigs of Millettia pubinervis Kurz, together with ten known flavonoids, karanjin (2), kanjone (3), 3,6-dimethoxy-[2,3:7,8] furanoflavone (4), pongaglabrone (5), pongapin (6), pongaflavone (7), 3,6-dimethoxy6,6-dimethylchromene-[2,3:7,8] flavone (8), pongachromene (9), 3,6-dimethoxy-3',4'-methylenedioxy-6,6-dimethylchromene-[2,3:7,8] flavone (10) and demethoxykanugin (11). This is the first phytochemical investigation of this plant. The structure of compound 1 was elucidated on the basis of spectroscopic data interpretation, including 1D and 2D NMR and HREIMS analysis. The cytotoxicity of 1 against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7 and SW480, was evaluated, but it was inactive (IC50>40 mu M). |
