| Title | Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans |
| Author | Xu, You-Kai |
| Publication | JOURNAL OF NATURAL PRODUCTS |
| Year | 2015 |
| Volume | 78 |
| Issue | 7 |
| Corresponding Author | Xu, YK |
| Abstract | Nine new alkaloids of the koumine (1-4), humantenine (5-7), and yohimbane (8, 9) types as well as 12 known analogues were isolated from the leaves and vine stems of Gelsemium elegans. Compound 1 is the first N-4-demethyl alkaloid of the koumine type, compound 7 is the first nor-humantenine alkaloid, and compounds 8 and 9 are the first N-1-oxide and the first seco-E-ring alkaloids, respectively, of the yohimbane type. Compounds 1 and 7 exhibited moderate cytotoxicity against five human tumor cell lines with IC50 values in the range 4.6-9.3 mu M. |
