| Title | Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae) |
| Author | Liu, Bing |
| Publication | NATURAL PRODUCT RESEARCH |
| Year | 2016 |
| Volume | 30 |
| Issue | 4 |
| Corresponding Author | Xu, YK |
| Abstract | Twelve compounds were isolated from the roots of Aglaia odorata. Their structures were established on the basis of NMR and MS data as rocaglaol (1), rocaglamide (2), eichlerialactone (3), sapelins A (4), isofouquierone (5), eichlerianic acid (6), shoreic acid (7), agladupol E (8), 3-epimeliantriol (9), cleomiscosins B (10), 2 beta,3 beta-dihydroxy-5 alpha-pregnane-16-one (11) and beta-D-glucopyranos-1-yl N-methylpyrrole-2-carboxylate (12). Among them, compounds 1 and 2 showed significant cytotoxicity against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480) with IC50 values of 0.007-0.095 mu M, while compounds 3-5 and 10 and 11 showed moderate to no cytotoxicity (IC50 0.43 to values >40 mu M). Compound 6 showed only weak cytotoxicity (IC50 6.87 to >40 mu M) and its epmier 7 was completely inactivite (IC50 >40 mu M) in the assay. However, potent synergistic effect was observed when the molar ratio of 6 to 7 is between 4: 1 and 1:1. |
