| Title | Natural Geranylated Sulfur-Containing Amides with Inhibitory Effect on Th17 Differentiation |
| Author | Ji, Kai-Long |
| Publication | CHEMISTRY & BIODIVERSITY |
| Year | 2023 |
| Volume | 20 |
| Issue | 6 |
| Corresponding Author | Ji, KL;Li, T |
| Abstract | Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds (1-10), including two previously unreported geranylated sulfurcontaining amides (1 and 2) and eight known ones (3-10). Structural characterization was carried out using comprehensive spectroscopic methods including NMR, MS and CD. The inhibitory effects of all isolates on Th17 differentiation were evaluated, of which compounds 1 and 6 significantly inhibited Th17 differentiation with IC50 values of 0.36 and 1.30 mu M, respectively, while both 1 and 6 failed to bind to retinoic acid-related orphan receptor gamma t (ROR gamma t), suggesting that their inhibition of Th17 differentiation is independent of ROR gamma t. |
