| Title | Unprecedented anti-adipogenic cadinane dimers from Stahlianthus involucratus: Discovery via an MS-MN-based activity-structure strategy |
| Author | Song, Xiu-Qing |
| Publication | CHINESE CHEMICAL LETTERS |
| Year | 2026 |
| Volume | 37 |
| Issue | 11 |
| Corresponding Author | Ji, KL |
| Abstract | Four pairs of cadinane sesquiterpenoid dimers, distahlianoids A-D ( 1 -4 ), featuring three distinct structural scaffolds, were isolated from the Dai medicinal plant Stahlianthus involucratus using a mass spectrometry (MS)-molecular networking (MN)-based activity-structure approach. Structurally, compound 1 exhibits a unique fused heptacyclic architecture comprising 5/6/6/6/6/6/5 ring system, characterized by a novel 9-methyl-2-oxabicyclo[3.3.1]nona-3,7-dien-9-ol core structure. Compounds 2 and 3 feature unusual 5/6/6/5/6/6/5 and 5/6/6/5/6/6 polycyclic frameworks, respectively. Compound 4 is a skeleton-rearranged dimer containing a unique 2-methyl-[2,2' -bifuran]-3,5' (2 H ,2' H )-dione motif. Given the enantiomeric nature of these compounds, their biosynthetic pathways were proposed, along with the stereoselective formation regularities. Compounds 1 -4 significantly inhibited lipid accumulation in 3T3-L1 adipocytes, with (-)- 4 showing the strongest effect (half maximal effective concentration (EC50 ) = 1.04 E 0.34 & micro;mol/L) and high selectivity (selectivity index (SI) > 96). (c) 2026 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
